MOLECULAR REGULATION OF ANGIOGENESIS AND VASCULAR HOMEOSTASIS

TRAINEE SPOTLIGHT

Margaret Ramirez Awarded Summer Research Grant by cureCADASIL

Margaret Ramirez, undergraduate researcher, was awarded a summer grant by cureCADASIL for her research project “Assessing NOTCH3 Activity in a Genetically Diverse Cohort of CADASIL Patients.” This was an 8-week exploratory study, directly supervised by Postdoctoral Fellow Milagros Romay, using post-mortem CADASIL brain biopsies and aged match controls to test the hypothesis that CADASIL is a loss-of-function in NOTCH signaling.

NEWS

Dr. Georg Hilfenhaus, post-doctoral fellow, communicates on the differences in barrier function in distinct vascular bed

Dr. Georg Hilfenhaus, post-doctoral fellow at the Arispe Lab, and collaborators (including 4 undergraduate trainees of the Lab: Dai Nguyen, Jonathan Freshman, Divya Prajapati and Dana Song) have a newly accepted paper in JCB showing Vav3, a GEF that regulates the cytoskeleton, is a critical regulator of barrier that is expressed in capillaries but is absent from large vessel endothelium.

Hilfenhaus, G., Nguyen, D., Freshman, J., Prajapati, D., Ma, F., Song, D., Ziyad, S., Cuadrado, M., Pellegrini, M., Busteo, X.R., Iruela-Arispe, M.L. 2018. VAV3-induced Cytoskeletal Dynamics Contribute to Heterotypic Properties of Endothelial Barriers. J Cell Biol. In Press.

VERY COOL

Farewell Researchers, New Adventures Lie Ahead

The Arispe Lab bids farewell to Dr. Julia Mack, Dr. Vanessa Freitas, and former undergrad trainee William (Will) Jones.